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The responses of brain acetylcholinesterase and plasma cholinesterase activities were examined in chicken given oral doses of an organophosphorus insecticides. Acute oral LD_(50) of terbufos was 1.82㎎/㎏, and terbufos sulfone was 2.85㎎/㎏, terbufos sulfoxide, terbufoso xon, terbufosoxon sulfone and terbufosoxon sulfoxide were about 0.30∼79㎎/㎏, respectively. Acute oral LD_(50) of phorate was 1.02㎎/㎏, and phorate sulfone was 1.73㎎/㎏, phorate sulfoxide, phoratoxon, phoratoxon sulfoxide and phoratoxon sulfone were about 0.36∼0.63㎎/㎏, respectively. Dosages of 50% inhibition for brain AChE and plasma ChE activities in chicken at 60 mins after oral administration of organop hosphorus insecticides were 35.3±6.8% and 17.4±3.6% of acute oral LD_(50), respectively. Activities of brain AChE and plasma ChE in chicken at 60 mins after oral administratration of acute oral LD_(50) of organophosphorus insecticides were inhibited by 83.7±3.9% and 93.3±2.2%, respectively.
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